| First Author | Sugiyama S | Year | 2005 |
| Journal | Biochem Biophys Res Commun | Volume | 337 |
| Issue | 1 | Pages | 271-4 |
| PubMed ID | 16182244 | Mgi Jnum | J:101520 |
| Mgi Id | MGI:3604223 | Doi | 10.1016/j.bbrc.2005.09.050 |
| Citation | Sugiyama S, et al. (2005) Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. Biochem Biophys Res Commun 337(1):271-4 |
| abstractText | We have previously found that epiregulin, a member of epidermal growth factor superfamily, is involved in proinflammatory cytokine production in bone marrow-derived macrophages. In this report, to further assess the role of epiregulin in innate immunity, we measured IL-6 production levels upon lipopolysaccharide and peptidoglycan stimulation in antigen presenting cells including macrophages and dendritic cells. Our analyses using epiregulin-deficient mice with mixed and inbred genetic backgrounds revealed that epiregulin deficiency results in the reduction of IL-6 production levels in both cell types upon peptidoglycan stimulation, and that the extent of this reduction is more evident under the BALB/c background compared with the C57BL/6J background. These results indicated that epiregulin may have a critical role in the regulation of peptidoglycan-mediated proinflammatory cytokine production in antigen presenting cells and innate immunity. |
