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Allele : Aipl1<tm1Visu> aryl hydrocarbon receptor-interacting protein-like 1; targeted mutation 1, Visvanathan Ramamurthy

Primary Identifier	MGI:3054793	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Aipl1
Transmission	Germline	Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

Exons 2-5 were replaced with a neomycin resistance gene. RT-PCR and immunoblot of retinas demonstrated lack of transcript and protein, respectively.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
Aipl1<->,
Aipl1<->

earliestPublication:
Ramamurthy V, et al. (2004) Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesterase. Proc Natl Acad Sci U S A 101(38):13897-902

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

14 Publication categories

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