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Allele : Prkaca<tm2Gsm> protein kinase, cAMP dependent, catalytic, alpha; targeted mutation 2, G Stanley McKnight

Primary Identifier	MGI:3054825	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Prkaca
Transmission	Germline	Strain of Origin	129X1/SvJ
Is Recombinase	false	Is Wild Type	false

molecularNote

This allele carries a loxP site and a mutation of the translation initiation codon in every reading frame in exon 1b. Western blot confirmed absence of protein in testes and sperm.

mutations:
Disruption caused by insertion of vector

cellLines:
Not Specified

earliestPublication:
Nolan MA, et al. (2004) Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A 101(37):13483-8

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

4 Publication categories

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