| First Author | Ju SY | Year | 2009 |
| Journal | Cell Biol Int | Volume | 33 |
| Issue | 1 | Pages | 31-5 |
| PubMed ID | 18992833 | Mgi Jnum | J:347741 |
| Mgi Id | MGI:7627180 | Doi | 10.1016/j.cellbi.2008.10.002 |
| Citation | Ju SY, et al. (2009) Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver. Cell Biol Int 33(1):31-5 |
| abstractText | Restricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24h. After hypoxic treatment, BMCs of apoptotic fraction were decreased. The expression of CXCR4 was noticeably increased in the hypoxia-treated BMCs and their migration in response to SDF-1alpha was enhanced compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher degree of engraftment to the CCl(4)-injured liver than the normoxic cells. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF-1alpha, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl(4) damaged liver. |
