| First Author | Kondo M | Year | 2013 |
| Journal | Learn Mem | Volume | 21 |
| Issue | 1 | Pages | 1-4 |
| PubMed ID | 24344177 | Mgi Jnum | J:312045 |
| Mgi Id | MGI:6782833 | Doi | 10.1101/lm.032193.113 |
| Citation | Kondo M, et al. (2013) The 5-HT3A receptor is essential for fear extinction. Learn Mem 21(1):1-4 |
| abstractText | The 5-HT3 receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT3A receptor knockout mice in fear conditioning paradigms revealed that the 5-HT3A receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT3A receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders. |
