| First Author | García-Martínez LF | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 5 | Pages | 2995-3001 |
| PubMed ID | 15322158 | Mgi Jnum | J:92721 |
| Mgi Id | MGI:3054335 | Doi | 10.4049/jimmunol.173.5.2995 |
| Citation | Garcia-Martinez LF, et al. (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol 173(5):2995-3001 |
| abstractText | Using a mouse mutagenesis screen, we have identified CD83 as being critical for the development of CD4(+) T cells and for their function postactivation. CD11c(+) dendritic cells develop and function normally in mice with a mutated CD83 gene but CD4(+) T cell development is substantially reduced. Additionally, we now show that those CD4(+) cells that develop in a CD83 mutant animal fail to respond normally following allogeneic stimulation. This is at least in part due to an altered cytokine expression pattern characterized by an increased production of IL-4 and IL-10 and diminished IL-2 production. Thus, in addition to its role in selection of CD4(+) T cells, absence of CD83 results in the generation of cells with an altered activation and cytokine profile. |
