| First Author | Lüthje K | Year | 2008 |
| Journal | Int Immunol | Volume | 20 |
| Issue | 8 | Pages | 949-60 |
| PubMed ID | 18544574 | Mgi Jnum | J:139358 |
| Mgi Id | MGI:3807810 | Doi | 10.1093/intimm/dxn054 |
| Citation | Luthje K, et al. (2008) CD83 regulates splenic B cell maturation and peripheral B cell homeostasis. Int Immunol 20(8):949-60 |
| abstractText | The central function of murine CD83 that is expressed on thymic epithelial cells is to induce the progression of double-positive thymocytes to single CD4-positive T cells. Several lines of evidence suggest an additional role for CD83 in the regulation of peripheral T and B cell responses. Here we show that CD83 is expressed by immature B cells and regulates their further maturation and survival in the periphery. Employing mixed bone marrow chimeras, we compare wild-type, CD83 over-expressing and CD83-deficient B cells within the same host. CD83 over-expression on the immature B cells themselves led to an accumulation of transitional B cells and a reciprocally reduced maturation of follicular B cells that was strictly correlated to the intensity of CD83 over-expression. The absence of CD83 on B cells resulted in a decreased maturation of marginal zone B cells and conferred a mild selection advantage for B cell survival in the periphery. Consenting with these findings, the over-expression of CD83 specifically and dose dependently interfered with homeostasis of B cells while T cell survival was not affected by CD83 over-expression over a period of 30 weeks. Taken together, our data suggest that CD83 negatively regulates B cell maturation and survival. |
