| First Author | Cheng IH | Year | 2004 |
| Journal | Nat Med | Volume | 10 |
| Issue | 11 | Pages | 1190-2 |
| PubMed ID | 15502844 | Mgi Jnum | J:100954 |
| Mgi Id | MGI:3590096 | Doi | 10.1038/nm1123 |
| Citation | Cheng IH, et al. (2004) Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med 10(11):1190-2 |
| abstractText | The Arctic mutation within the amyloid-beta (Abeta) peptide causes Alzheimer disease. In vitro, Arctic-mutant Abeta forms (proto)fibrils more effectively than wild-type Abeta. We generated transgenic mouse lines expressing Arctic-mutant human amyloid precursor proteins (hAPP). Amyloid plaques formed faster and were more extensive in Arctic mice than in hAPP mice expressing wild-type Abeta, even though Arctic mice had lower Abeta(1-42/1-40) ratios. Thus, the Arctic mutation is highly amyloidogenic in vivo. |
