| First Author | Giasson BI | Year | 2003 |
| Journal | Science | Volume | 300 |
| Issue | 5619 | Pages | 636-40 |
| PubMed ID | 12714745 | Mgi Jnum | J:127923 |
| Mgi Id | MGI:3765219 | Doi | 10.1126/science.1082324 |
| Citation | Giasson BI, et al. (2003) Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 300(5619):636-40 |
| abstractText | Alpha-synuclein (alpha-syn) and tau polymerize into amyloid fibrils and form intraneuronal filamentous inclusions characteristic of neurodegenerative diseases. We demonstrate that alpha-syn induces fibrillization of tau and that coincubation of tau and alpha-syn synergistically promotes fibrillization of both proteins. The in vivo relevance of these findings is grounded in the co-occurrence of alpha-syn and tau filamentous amyloid inclusions in humans, in single transgenic mice that express A53T human alpha-syn in neurons, and in oligodendrocytes of bigenic mice that express wild-type human alpha-syn plus P301L mutant tau. This suggests that interactions between alpha-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases. |
