| First Author | Shi SX | Year | 2023 |
| Journal | Sci Adv | Volume | 9 |
| Issue | 23 | Pages | eabq0712 |
| PubMed ID | 37285421 | Mgi Jnum | J:350843 |
| Mgi Id | MGI:7489170 | Doi | 10.1126/sciadv.abq0712 |
| Citation | Shi SX, et al. (2023) CD4(+) T cells aggravate hemorrhagic brain injury. Sci Adv 9(23):eabq0712 |
| abstractText | Leukocyte infiltration accelerates brain injury following intracerebral hemorrhage (ICH). Yet, the involvement of T lymphocytes in this process has not been fully elucidated. Here, we report that CD4(+) T cells accumulate in the perihematomal regions in the brains of patients with ICH and ICH mouse models. T cells activation in the ICH brain is concurrent with the course of perihematomal edema (PHE) development, and depletion of CD4(+) T cells reduced PHE volumes and improved neurological deficits in ICH mice. Single-cell transcriptomic analysis revealed that brain-infiltrating T cells exhibited enhanced proinflammatory and proapoptotic signatures. Consequently, CD4(+) T cells disrupt the blood-brain barrier integrity and promote PHE progression through interleukin-17 release; furthermore, the TRAIL-expressing CD4(+) T cells engage DR5 to trigger endothelial death. Recognition of T cell contribution to ICH-induced neural injury is instrumental for designing immunomodulatory therapies for this dreadful disease. |
