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Allele : Tg(TcrbAI4)1Dvs transgene insertion 1, David V Serreze
Primary Identifier  MGI:3057181 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(TcrbAI4)1Dvs
Strain of Origin  NOD/ShiLt Is Recombinase  false
Is Wild Type  false
description  In conjunction with Rag1tm1Mom
    transgenic mice carrying both the alpha and beta AI4 TCR transgenes exhibit an accelerated development of insulin-dependent diabetes mellitus (IDDM).
    homozygous mice are viable and fertile
molecularNote  The rearranged Tcrb transgene expressed in these mice is derived from the pancreatic beta cell-reactive CD8 T lymphocyte clone AI4. The transgenic construct contains a Tcrb-V2/Tcrb-D/Tcrb-J cDNA segment.
  • mutations:
  • Insertion
  • synonyms:
  • AI4bTg,
  • AI4bTg
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

13 Carried By

0 Driven By

17 Publication categories





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