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Allele : Irs2<tm2Mfw> insulin receptor substrate 2; targeted mutation 2, Morris F White

Primary Identifier	MGI:3497903	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Irs2
Transmission	Germline	Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

A targeting vector was designed to flank the coding region with loxP sites. Transient expression of a Cre plasmid excised a floxed neo that had be included in the 5' region of the vector.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
fIrs2,
Irs2<L>,
Irs2<L>,
fIrs2

earliestPublication:
Lin X, et al. (2004) Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 114(7):908-16

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

32 Publication categories

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