| First Author | Sakamoto T | Year | 2011 |
| Journal | Peptides | Volume | 32 |
| Issue | 5 | Pages | 1020-6 |
| PubMed ID | 21356261 | Mgi Jnum | J:309890 |
| Mgi Id | MGI:6708761 | Doi | 10.1016/j.peptides.2011.02.015 |
| Citation | Sakamoto T, et al. (2011) Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice. Peptides 32(5):1020-6 |
| abstractText | Intracerebroventricular (icv) injection of neuromedin S (NMS) in mice increased the heart rate in a dose-dependent manner. On the other hand, genetically NMS deficient mice (NMS-KO mice) exhibited a decreased heart rate and significant extension of the QRS and PR interval in the electrocardiogram complex. Although treatment with a parasympathetic nerve blocker, methylscopolamine, and a sympathetic nerve blocker, timolol, respectively increased and decreased the heart rate in both NMS-KO and wild-type mice, the extent of the decrease induced by timolol was smaller in NMS-KO than in wild-type mice. In addition, pretreatment with timolol completely inhibited the NMS-induced heart rate increase in wild-type mice. No expression of mRNA for NMS or the NMS receptor was evident in the heart by RT-PCR analysis. These results suggest that endogenous NMS may regulate cardiovascular function by activating the sympathetic nervous system. |
