| Primary Identifier | MGI:3057188 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(GFAP-APOE_i3)37Hol |
| Strain of Origin | C57BL/6 and CBA | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene contains sequence encoding human apolipoprotein E3 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Two lines were created (lines 2 and 37) with line 37 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. |
