| First Author | Carr T | Year | 2015 |
| Journal | J Exp Med | Volume | 212 |
| Issue | 5 | Pages | 793-807 |
| PubMed ID | 25897173 | Mgi Jnum | J:222696 |
| Mgi Id | MGI:5645401 | Doi | 10.1084/jem.20141849 |
| Citation | Carr T, et al. (2015) The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation. J Exp Med 212(5):793-807 |
| abstractText | Invariant natural killer T cells (iNKT cells) are innate-like T cells that rapidly produce cytokines that impact antimicrobial immune responses, asthma, and autoimmunity. These cells acquire multiple effector fates during their thymic development that parallel those of CD4(+) T helper cells. The number of Th2-type effector iNKT cells is variable in different strains of mice, and their number impacts CD8 T, dendritic, and B cell function. Here we demonstrate a unique function for the transcription factor lymphoid enhancer factor 1 (LEF1) in the postselection expansion of iNKT cells through a direct induction of the CD127 component of the receptor for interleukin-7 (IL-7) and the transcription factor c-myc. LEF1 also directly augments expression of the effector fate-specifying transcription factor GATA3, thus promoting the development of Th2-like effector iNKT cells that produce IL-4, including those that also produce interferon-gamma. Our data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation. |
