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Allele : Ret<tm3(RET)Jmi> ret proto-oncogene; targeted mutation 3, Jeffrey Milbrandt

Primary Identifier	MGI:3487229	Allele Type	Targeted
Gene	Ret	Transmission	Germline
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

Human RET9 cDNA with Y1062F and L985P mutations and a floxed neo were inserted into exon 1 of the endogenous locus. Leucine 985 was at the end of the kinase domain.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Ret<DNneo>,
Ret<DNneo>

earliestPublication:
Jain S, et al. (2004) Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development 131(21):5503-13

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

5 Publication categories

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