| First Author | Holers VM | Year | 1993 |
| Journal | J Immunol | Volume | 151 |
| Issue | 9 | Pages | 5041-52 |
| PubMed ID | 8409455 | Mgi Jnum | J:93556 |
| Mgi Id | MGI:3057303 | Doi | 10.4049/jimmunol.151.9.5041 |
| Citation | Holers VM, et al. (1993) Induction of peri-insulitis but not diabetes in islet transplants expressing a single foreign antigen. A multi-stage model of disease. J Immunol 151(9):5041-52 |
| abstractText | We have created a new transgenic model in which the human Epstein-Barr virus receptor, CR2 (CD21), has been expressed in pancreatic beta-cells. Mice derived from three transgenic founders bred into H-2b (C57BL/6) or H-2k (CBA) genetic backgrounds did not become spontaneously diabetic. After transplantation of CR2-expressing islets under the kidney capsule of genetically matched recipients, a histologic picture of peri-insulitis was found. However, animals did not manifest cellular invasion of the islets, destruction of the islets, or diabetes for at least 230 days. Significant numbers of both T and B lymphocytes were found in the cell population surrounding the islets. A pronounced serologic response to CR2 was also present and appeared to precede the onset of peri-insulitis. Thus, in this model, we have separated the process of diabetes induction into at least two phases. One is associated with peri-islet infiltration and an antibody response. However, at least one second signal is likely necessary for the process of islet destruction to follow. |
