| First Author | Zhang W | Year | 2016 |
| Journal | Nat Neurosci | Volume | 19 |
| Issue | 4 | Pages | 557-559 |
| PubMed ID | 26900927 | Mgi Jnum | J:234511 |
| Mgi Id | MGI:5790147 | Doi | 10.1038/nn.4257 |
| Citation | Zhang W, et al. (2016) Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders. Nat Neurosci 19(4):557-9 |
| abstractText | Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown. Using TDP-43(A315T) mice, an ALS and FTD model with marked cortical pathology, we found that hyperactive somatostatin interneurons disinhibited layer 5 pyramidal neurons (L5-PNs) and contributed to their excitotoxicity. Focal ablation of somatostatin interneurons efficiently restored normal excitability of L5-PNs and alleviated neurodegeneration, suggesting a new therapeutic target for ALS and FTD. |
