| First Author | Li J | Year | 2023 |
| Journal | Cell Biol Int | Volume | 47 |
| Issue | 12 | Pages | 1942-1949 |
| PubMed ID | 37615370 | Mgi Jnum | J:345956 |
| Mgi Id | MGI:7611769 | Doi | 10.1002/cbin.12082 |
| Citation | Li J, et al. (2023) PDGF-C promotes cell proliferation partially via downregulating BOP1. Cell Biol Int 47(12):1942-1949 |
| abstractText | Platelet-derived growth factor C (PDGF-C) is a member of PDGF/VEGF family, which is well-known for important functions in the vascular system. It is widely reported that PDGF-C is able to modulate cell proliferation. However, it is still not very clear about this cell modulating mechanism at the molecular level. In a screening of factors regulated by PDGF-C protein, we fished out a factor called block of proliferation 1 (BOP1), which is a pivotal regulator of ribosome biogenesis and cell proliferation. In this study, we investigated the regulation of BOP1 by PDGF-C and its role in modulating cell proliferation. We found that BOP1 was downregulated at both mRNA and protein levels in cells treated with PDGF-C-containing conditioned medium. On the other hand, BOP1 was upregulated in PDGF-C deficient mice. Furthermore, we confirmed that overexpression of BOP1 inhibited HEK293A cell proliferation, whereas knockdown of BOP1 promoted cell proliferation. The mitogenic effect of PDGF-C could be attenuated by downregulation of BOP1. Our results demonstrate a clear PDGF-C-BOP1 signaling that modulates cell proliferation. |
