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Publication : FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus.

First Author  Suzuki S Year  1975
Journal  Jpn J Exp Med Volume  45
Issue  6 Pages  473-8
PubMed ID  1232464 Mgi Jnum  J:5684
Mgi Id  MGI:54161 Citation  Suzuki S (1975) FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus. Jpn J Exp Med 45(6):473-8
abstractText  Analysis of offsprings from mating of a Friend leukemia virus (FLV) resistant new mouse line, G, and DBA/S mice confirmed the existence of a single dominant gene for the resistance of G to FLV. In these offsprings, no correlation between resistance to FLV and hair-color genes (b, d and c) were observed. In the progeny of ((G X BALB/c) X DBA/2) mating, the resistance gene seregated independently from Fv-1. The allele(s) on Fv-1 locus in G mice seemed to be permissive to N-tropic virus. Therefore, conconmitance of Fv-1b in G mice was excluded. These results indicated that the resistance gene in the new line mice differ from Fv-1 and Fv-2.
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