| First Author | Kallies A | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 5 | Pages | 466-74 |
| PubMed ID | 16565720 | Mgi Jnum | J:112557 |
| Mgi Id | MGI:3662778 | Doi | 10.1038/ni1321 |
| Citation | Kallies A, et al. (2006) Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol 7(5):466-74 |
| abstractText | T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of terminal B cell differentiation, was expressed in a subset of antigen-experienced CD4(+) and CD8(+) T cells. Mice reconstituted with fetal liver stem cells expressing a mutant Blimp-1 lacking the DNA-binding domain developed a lethal multiorgan inflammatory disease caused by an accumulation of effector and memory T cells. These data identify Blimp-1 as an essential regulator of T cell homeostasis and suggest that Blimp-1 regulates both B cell and T cell differentiation. |
