| First Author | Andreani V | Year | 2018 |
| Journal | Proc Natl Acad Sci U S A | Volume | 115 |
| Issue | 41 | Pages | E9630-E9639 |
| PubMed ID | 30257949 | Mgi Jnum | J:266413 |
| Mgi Id | MGI:6202826 | Doi | 10.1073/pnas.1809739115 |
| Citation | Andreani V, et al. (2018) Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and beta1-integrin function. Proc Natl Acad Sci U S A 115(41):E9630-E9639 |
| abstractText | Plasma cell differentiation involves coordinated changes in gene expression and functional properties of B cells. Here, we study the role of Mzb1, a Grp94 cochaperone that is expressed in marginal zone (MZ) B cells and during the terminal differentiation of B cells to antibody-secreting cells. By analyzing Mzb1 (-/-) Prdm1 (+/gfp) mice, we find that Mzb1 is specifically required for the differentiation and function of antibody-secreting cells in a T cell-independent immune response. We find that Mzb1-deficiency mimics, in part, the phenotype of Blimp1 deficiency, including the impaired secretion of IgM and the deregulation of Blimp1 target genes. In addition, we find that Mzb1 (-/-) plasmablasts show a reduced activation of beta1-integrin, which contributes to the impaired plasmablast differentiation and migration of antibody-secreting cells to the bone marrow. Thus, Mzb1 function is required for multiple aspects of plasma cell differentiation. |
