| First Author | Zhang M | Year | 2018 |
| Journal | Dev Cell | Volume | 46 |
| Issue | 4 | Pages | 397-409.e5 |
| PubMed ID | 30130530 | Mgi Jnum | J:267671 |
| Mgi Id | MGI:6269234 | Doi | 10.1016/j.devcel.2018.07.021 |
| Citation | Zhang M, et al. (2018) Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration. Dev Cell 46(4):397-409.e5 |
| abstractText | Melanocortin 4 receptor (Mc4r) plays a crucial role in the central control of energy homeostasis, but its role in peripheral organs has not been fully explored. We have investigated the roles of hypothalamus-mediated energy metabolism during Xenopus limb regeneration. We report that hypothalamus injury inhibits Xenopus tadpole limb regeneration. By loss-of-function and gain-of-function studies, we show that Mc4r signaling is required for limb regeneration in regeneration-competent tadpoles and stimulates limb regeneration in later-stage regeneration-defective tadpoles. It regulates limb regeneration through modulating energy homeostasis and ROS production. Even more interestingly, our results demonstrate that Mc4r signaling is regulated by innervation and alpha-MSH substitutes for the effect of nerves in limb regeneration. Mc4r signaling is also required for mouse digit regeneration. Thus, our findings link vertebrate limb regeneration with Mc4r-mediated energy homeostasis and provide a new avenue for understanding Mc4r signaling in the peripheral organs. |
