| Primary Identifier | MGI:3512308 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Alb1-Myc)#Sst |
| Strain of Origin | (C57BL/6 x CBA)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Four lines were generated: 166.8, 178.3, 181.2, and 179.2 Line 166.8 has a 40kb deletion in the Gtf2ird1 gene, causing a hypomorph allele with craniofacial defects. |
| molecularNote | The insertion of the Myc transgene also deleted approximately 40 kb of chromosome 5 at the insertion site, encompassing sequence downstream of Cyln2 through the first exon of Gtf2ird1. Northern blot and RT-PCR analysis of heart, muscle, liver, and spleen tissue from homozygous mutant mice showed highly reduced levels of Gtf2ird1 transcript. |
