| First Author | Onimaru H | Year | 2004 |
| Journal | Brain Res Dev Brain Res | Volume | 153 |
| Issue | 2 | Pages | 275-9 |
| PubMed ID | 15527896 | Mgi Jnum | J:109165 |
| Mgi Id | MGI:3626029 | Doi | 10.1016/j.devbrainres.2004.09.007 |
| Citation | Onimaru H, et al. (2004) In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla. Brain Res Dev Brain Res 153(2):275-9 |
| abstractText | To clarify the neuronal organization of the respiratory center of the mouse, we analyzed the spatio-temporal pattern of respiratory neuron activity in the ventral medulla of a newborn mouse preparation, using optical recordings. We also demonstrated optical images of the respiratory activity of two different lines of knock-out mice (Tlx3-/-, Pbx3-/-) that exhibit respiratory failure leading to neonatal death from dysfunction of central respiratory neuron activity. In the wild type mice, the respiratory neuron activity in the para-facial region of the rostral medulla appeared prior to inspiratory activity in the more caudal ventrolateral medulla. This rostral to caudal activity pattern was basically preserved in Tlx3-/- mice though the activity was more dispersed and weaker than in the wild type mice. Such an activity pattern was not clearly detected in Pbx3-/- mouse preparations. The difference in the spatio-temporal pattern between Tlx3-/- and Pbx3-/- suggests different levels of functional disorder of the respiratory center. |
