| First Author | Mori M | Year | 2008 |
| Journal | J Biol Chem | Volume | 283 |
| Issue | 43 | Pages | 29011-21 |
| PubMed ID | 18667426 | Mgi Jnum | J:142476 |
| Mgi Id | MGI:3821557 | Doi | 10.1074/jbc.M804539200 |
| Citation | Mori M, et al. (2008) Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors. J Biol Chem 283(43):29011-21 |
| abstractText | Overexpression of JAB1 is observed in a variety of human cancers, but how JAB1 is involved in tumor development remained to be investigated. Here we analyzed mice with modified Jab1 expression. Mice ectopically expressing a more stable form of JAB1 protein under the control of a constitutive promoter were rescued from the embryonic lethality caused by the Jab1(-/-) allele and developed a myeloproliferative disorder in a gene dosage-dependent manner. Hematopoietic cells from the bone marrow of Jab1 transgenic mice had a significantly larger stem cell population and exhibited higher and transplantable proliferative potential. In contrast, Jab1(+/-) mice, which express approximately 70% as much JAB1 protein as their wild-type littermates, showed inefficient hematopoiesis. Expression of the tumor suppressor p16(INK4a) was inversely correlated with that of JAB1, and the oncoprotein SMYD3, a newly identified JAB1 interactor, suppressed transcription of p16 in cooperation with JAB1. Thus, the expression and function of JAB1 are critical for the proliferation and maintenance of hematopoietic progenitors. |
