| Primary Identifier | MGI:3511285 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Lepr |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Leprtm1.1Chua mice crossed with Cre transgenic mice created this allele in which exon 17 is excised. The predicted result is a truncated receptor protein for all isoforms, with a frameshift in the 3' end of exon 16, thus causing a Lepr-B terminal exon consisting of 14 amino acids and a premature stop codon. RT-PCR confirmed the deletion. |
