| First Author | Xu H | Year | 1998 |
| Journal | J Exp Med | Volume | 188 |
| Issue | 7 | Pages | 1247-54 |
| PubMed ID | 9763604 | Mgi Jnum | J:115200 |
| Mgi Id | MGI:3690836 | Doi | 10.1084/jem.188.7.1247 |
| Citation | Xu H, et al. (1998) Regulation of anti-DNA B cells in recombination-activating gene-deficient mice. J Exp Med 188(7):1247-54 |
| abstractText | Anti-DNA antibodies are regulated in normal individuals but are found in high concentration in the serum of systemic lupus erythematosus (SLE) patients and the MRL lpr/lpr mouse model of SLE. We previously studied the regulation of anti-double-stranded (ds)DNA and anti-single-stranded (ss)DNA B cells in a nonautoimmune background by generating mice carrying immunoglobulin transgenes coding for anti-DNAs derived from MRL lpr/lpr. Anti-dsDNA B cells undergo receptor editing, but anti-ssDNA B cells seem to be functionally silenced. Here we have investigated how anti-DNA B cells are regulated in recombination- activating gene (RAG)-2-/- mice. In this setting, anti-dsDNA B cells are eliminated by apoptosis in the bone marrow and anti-ssDNA B cells are partially activated. |
