| First Author | Fusco J | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Issue | 1 | Pages | 9100 |
| PubMed ID | 28831150 | Mgi Jnum | J:256470 |
| Mgi Id | MGI:6108522 | Doi | 10.1038/s41598-017-09898-4 |
| Citation | Fusco J, et al. (2017) GLP-1/Exendin-4 induces beta-cell proliferation via the epidermal growth factor receptor. Sci Rep 7(1):9100 |
| abstractText | Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion. In rodents, and possibly in humans, exendin-4 can stimulate beta-cell proliferation. The exact mechanism of action to induce beta-cell proliferation is not well understood. Here, using a beta-cell specific epidermal growth factor receptor (EGFR) null mouse, we show that exendin-4 induced an increase in proliferation and beta-cell mass through EGFR. Thus, our study sheds light on the role of EGFR signaling in the effects of exendin-4 on the control of blood glucose metabolism and beta-cell mass. |
