| First Author | Liu KH | Year | 2013 |
| Journal | Cancer Lett | Volume | 340 |
| Issue | 1 | Pages | 22-9 |
| PubMed ID | 23811286 | Mgi Jnum | J:204351 |
| Mgi Id | MGI:5532278 | Doi | 10.1016/j.canlet.2013.06.024 |
| Citation | Liu KH, et al. (2013) P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1alpha. Cancer Lett 340(1):22-9 |
| abstractText | P21 activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/beta-catenin and Ras oncogene, which promote CRC survival via stimulation of hypoxia-inducible factor 1alpha (HIF-1alpha). The aim of this study was to assess the mechanism involved in the stimulation by PAK1 of CRC survival. PAK1 promoted CRC cell survival by up-regulation of HIF-1alpha. PAK1 was over-expressed and hyper-activated in tumors of ApcDelta(14/+) mice, which was correlated with over-expression of HIF-1alpha and beta-catenin. Inhibition of PAK1 decreased tumor growth and the expression of HIF-1alpha and beta-catenin in tumors of ApcDelta(14/+) mice, and suppressed xenograft tumor survival in SCID mice. These findings indicate that PAK1 stimulates CRC survival by up-regulation of HIF-1alpha. |
