| First Author | Cheunsuk S | Year | 2005 |
| Journal | Mol Cell Biol | Volume | 25 |
| Issue | 2 | Pages | 789-96 |
| PubMed ID | 15632078 | Mgi Jnum | J:94751 |
| Mgi Id | MGI:3513925 | Doi | 10.1128/MCB.25.2.789-796.2005 |
| Citation | Cheunsuk S, et al. (2005) Prss16 is not required for T-cell development. Mol Cell Biol 25(2):789-96 |
| abstractText | PRSS16 is a serine protease expressed exclusively in cortical thymic epithelial cells (cTEC) of the thymus, suggesting that it plays a role in the processing of peptide antigens during the positive selection of T cells. Moreover, the human PRSS16 gene is encoded in a region near the class I major histocompatibility complex (MHC) that has been linked to type 1 diabetes mellitus susceptibility. The mouse orthologue Prss16 is conserved in genetic structure, sequence, and pattern of expression. To study the role of Prss16 in thymic development, we generated a deletion mutant of Prss16 and characterized T-lymphocyte populations and MHC class II expression on cortical thymic epithelial cells. Prss16-deficient mice develop normally, are fertile, and show normal thymic morphology, cellularity, and anatomy. The total numbers and frequencies of thymocytes and splenic T-cell populations did not differ from those of wild-type controls. Surface expression of MHC class II on cTEC was also similar in homozygous mutant and wild-type animals, and invariant chain degradation was not impaired by deletion of Prss16. These findings suggest that Prss16 is not required for quantitatively normal T-cell development. |
