| First Author | Piazzon N | Year | 2015 |
| Journal | J Transl Med | Volume | 13 |
| Pages | 103 | PubMed ID | 25888842 |
| Mgi Jnum | J:320382 | Mgi Id | MGI:6871845 |
| Doi | 10.1186/s12967-015-0463-7 | Citation | Piazzon N, et al. (2015) Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression. J Transl Med 13:103 |
| abstractText | BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous fluid-filled cysts that frequently result in end-stage renal disease. While promising treatment options are in advanced clinical development, early diagnosis and follow-up remain a major challenge. We therefore evaluated the diagnostic value of Fetuin-A as a new biomarker of ADPKD in human urine. RESULTS: We found that renal Fetuin-A levels are upregulated in both Pkd1 and Bicc1 mouse models of ADPKD. Measurement by ELISA revealed that urinary Fetuin-A levels were significantly higher in 66 ADPKD patients (17.5 +/- 12.5 mug/mmol creatinine) compared to 17 healthy volunteers (8.5 +/- 3.8 mug/mmol creatinine) or 50 control patients with renal diseases of other causes (6.2 +/- 2.9 mug/mmol creatinine). Receiver operating characteristics (ROC) analysis of urinary Fetuin-A levels for ADPKD rendered an optimum cut-off value of 12.2 mug/mmol creatinine, corresponding to 94% of sensitivity and 60% of specificity (area under the curve 0.74 ; p = 0.0019). Furthermore, urinary Fetuin-A levels in ADPKD patients correlated with the degree of renal insufficiency and showed a significant increase in patients with preserved renal function followed for two years. CONCLUSIONS: Our findings establish urinary Fetuin-A as a sensitive biomarker of the progression of ADPKD. Further studies are required to examine the pathogenic mechanisms of elevated renal and urinary Fetuin-A in ADPKD. |
