| First Author | Tenner K | Year | 2008 |
| Journal | Neurosci Lett | Volume | 431 |
| Issue | 1 | Pages | 21-5 |
| PubMed ID | 18082956 | Mgi Jnum | J:141642 |
| Mgi Id | MGI:3819063 | Doi | 10.1016/j.neulet.2007.11.012 |
| Citation | Tenner K, et al. (2008) The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains. Neurosci Lett 431(1):21-5 |
| abstractText | Tryptophan hydroxylase 2 (TPH2) is the rate limiting enzyme of serotonin synthesis in the brain. A recently described functional (C1473G) single nucleotide polymorphism in mouse TPH2 resulting in vitro in a strongly decreased enzymatic activity was suspected to be responsible for the observed differences in 5-HT levels and behaviour between mice strains. We bred two substrains of C57BL/6 mice carrying the two isoforms and could show that both exhibit equal TPH activity, brain 5-HT content and behaviour. These data indicate that the distinct behavioural characteristics of mouse strains are not due to differences in TPH2 activity, but to other variations in the genetic background. |
