| First Author | Soula M | Year | 2023 |
| Journal | Nat Neurosci | Volume | 26 |
| Issue | 4 | Pages | 570-578 |
| PubMed ID | 36879142 | Mgi Jnum | J:348188 |
| Mgi Id | MGI:7486669 | Doi | 10.1038/s41593-023-01270-2 |
| Citation | Soula M, et al. (2023) Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer's disease model mice. Nat Neurosci 26(4):570-578 |
| abstractText | There is a demand for noninvasive methods to ameliorate disease. We investigated whether 40-Hz flickering light entrains gamma oscillations and suppresses amyloid-beta in the brains of APP/PS1 and 5xFAD mouse models of Alzheimer's disease. We used multisite silicon probe recording in the visual cortex, entorhinal cortex or the hippocampus and found that 40-Hz flickering simulation did not engage native gamma oscillations in these regions. Additionally, spike responses in the hippocampus were weak, suggesting 40-Hz light does not effectively entrain deep structures. Mice avoided 40-Hz flickering light, associated with elevated cholinergic activity in the hippocampus. We found no reliable changes in plaque count or microglia morphology by either immunohistochemistry or in vivo two-photon imaging following 40-Hz stimulation, nor reduced levels of amyloid-beta 40/42. Thus, visual flicker stimulation may not be a viable mechanism for modulating activity in deep structures. |
