Primary Identifier | MGI:3524971 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Aipl1 |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neo replaced exons 1 and 2, which contain the start codon and a portion of the sequence encoding the first TPR motif. Western blot confirmed that the mutation results in a null protein. Real time PCR and microarray hybridization of retinal cDNA further showed that mRNA was reduced in mutant retinae. |