| First Author | Ohno T | Year | 2004 |
| Journal | Immunogenetics | Volume | 56 |
| Issue | 9 | Pages | 675-8 |
| PubMed ID | 15536567 | Mgi Jnum | J:94127 |
| Mgi Id | MGI:3511366 | Doi | 10.1007/s00251-004-0739-1 |
| Citation | Ohno T, et al. (2004) Detection of a new cerebral malaria susceptibility locus, using CBA mice. Immunogenetics 56(9):675-8 |
| abstractText | Human cerebral malaria (CM) during acute Plasmodium falciparum infection is a serious neurological complication that leads to coma and death. P. berghei ANKA infection of CBA mice is a useful experimental model of CM. To identify host susceptibility loci, we performed chromosomal mapping in crossbred populations of both CM-susceptible CBA and CM-resistant DBA/2 mice. One significant region for a CM-susceptible locus in CBA mice was mapped to H2 region on Chromosome 17, tentatively designated cmsc. cmsc was mapped to a different chromosomal region from that previously reported in the C57BL/6 mouse model of CM. It is possible that different loci contribute to CM in CBA and C57BL/6 mouse strains. Comparison of the function of CM susceptibility loci between CBA and C57BL/6 mice could have important implications for the study of the complex pathogenesis of CM in humans. |
