| Primary Identifier | MGI:3525208 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Plce1 |
| Transmission | Germline | Strain of Origin | 129/Sv |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A PGK-neo was inserted to replace the 3' end of one of the four exons encoding the X domain. RT-PCR demonstrated the presence of a shortened transcript in mutant heart samples. Sequence analysis revealed a deletion of another upstream exon, presumably caused by exon skipping upon RNA splicing. The resulting allele contains an in-frame deletion of amino acids 1333 to 1408, corresponding to the amino terminal end of the catalytic X domain. |
