| First Author | Chen Y | Year | 2014 |
| Journal | Behav Brain Res | Volume | 275 |
| Pages | 219-24 | PubMed ID | 25192635 |
| Mgi Jnum | J:217218 | Mgi Id | MGI:5613322 |
| Doi | 10.1016/j.bbr.2014.08.042 | Citation | Chen Y, et al. (2014) Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice. Behav Brain Res 275:219-24 |
| abstractText | There is a close neuroanatomical connection between odor and emotional processing. Olfactory dysfunction is found in various neurodegenerative and neuropsychiatric disorders. Here, mice take the cyclic nucleotide gated channel 2 mutant gene (Cnga2), which is critical for olfactory sensory neurons to generate odor induced action potentials were used. The Cnga2 mice were congenitally anosmic. Adult mice were tested in a series behavioral paradigm such as open field, light/dark box, forced swim test and Y-maze. Our study found that Cnga2 mice showed increased anxiety- and depressive-like behaviors than their wide type siblings. However, Cnga2 mice showed no difference from the wide types when tested in the two-trial recognition Y-maze. The results indicate that innate olfactory deficiency might modulate emotional behaviors in mice. |
