| First Author | Kanno T | Year | 2010 |
| Journal | Neuroscience | Volume | 171 |
| Issue | 4 | Pages | 973-80 |
| PubMed ID | 20950672 | Mgi Jnum | J:170169 |
| Mgi Id | MGI:4944104 | Doi | 10.1016/j.neuroscience.2010.10.021 |
| Citation | Kanno T, et al. (2010) Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. Neuroscience 171(4):973-80 |
| abstractText | Although the hippocampus is a brain region involved in short-term memory, the molecular mechanisms underlying memory formation are not completely understood. Here we show that sphingosine 1-phosphate (S1P) plays a pivotal role in the formation of memory. Addition of S1P to rat hippocampal slices increased the rate of AMPA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) recorded from the CA3 region of the hippocampus. In addition long-term potentiation (LTP) observed in the CA3 region was potently inhibited by a sphingosine kinase (SphK) inhibitor and this inhibition was fully reversed by S1P. LTP was impaired in hippocampal slices specifically in the CA3 region obtained from SphK1-knockout mice, which correlates well with the poor performance of these animals in the Morris water maze test. These results strongly suggest that SphK/S1P receptor signaling plays an important role in excitatory synaptic transmission in the CA3 region of hippocampus and has profound effects on hippocampal function such as spatial learning. |
