| First Author | Zhang Q | Year | 2022 |
| Journal | Cell Rep | Volume | 41 |
| Issue | 9 | Pages | 111718 |
| PubMed ID | 36450244 | Mgi Jnum | J:332000 |
| Mgi Id | MGI:7407958 | Doi | 10.1016/j.celrep.2022.111718 |
| Citation | Zhang Q, et al. (2022) Food-induced dopamine signaling in AgRP neurons promotes feeding. Cell Rep 41(9):111718 |
| abstractText | Obesity comorbidities such as diabetes and cardiovascular disease are pressing public health concerns. Overconsumption of calories leads to weight gain; however, neural mechanisms underlying excessive food consumption are poorly understood. Here, we demonstrate that dopamine receptor D1 (Drd1) expressed in the agouti-related peptide/neuropeptide Y (AgRP/NPY) neurons of the arcuate hypothalamus is required for appropriate responses to a high-fat diet (HFD). Stimulation of Drd1 and AgRP/NPY co-expressing arcuate neurons is sufficient to induce voracious feeding. Delivery of a HFD after food deprivation acutely induces dopamine (DA) release in the ARC, whereas animals that lack Drd1 expression in ARC(AgRP/NPY) neurons (Drd1(AgRP)-KO) exhibit attenuated foraging and refeeding of HFD. These results define a role for the DA input to the ARC that encodes acute responses to food and position Drd1 signaling in the ARC(AgRP/NPY) neurons as an integrator of the hedonic and homeostatic neuronal feeding circuits. |
