| First Author | Kleszka K | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 19146 |
| PubMed ID | 33154420 | Mgi Jnum | J:299990 |
| Mgi Id | MGI:6491175 | Doi | 10.1038/s41598-020-75838-4 |
| Citation | Kleszka K, et al. (2020) Hypoxia-inducible factor-2alpha is crucial for proper brain development. Sci Rep 10(1):19146 |
| abstractText | Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells to hypoxia. However, even under atmospheric O2 conditions stabilized HIF-2alpha protein was found in brains of adult mice. Mice with a neuro-specific knockout of Hif-2alpha showed a reduction of pyramidal neurons in the retrosplenial cortex (RSC), a brain region responsible for a range of cognitive functions, including memory and navigation. Accordingly, behavioral studies showed disturbed cognitive abilities in these mice. In search of the underlying mechanisms for the specific loss of pyramidal cells in the RSC, we found deficits in migration in neural stem cells from Hif-2alpha knockout mice due to altered expression patterns of genes highly associated with neuronal migration and positioning. |
