| First Author | Soriano SG | Year | 2002 |
| Journal | J Neuroimmunol | Volume | 125 |
| Issue | 1-2 | Pages | 59-65 |
| PubMed ID | 11960641 | Mgi Jnum | J:95634 |
| Mgi Id | MGI:3526668 | Doi | 10.1016/s0165-5728(02)00033-4 |
| Citation | Soriano SG, et al. (2002) Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury. J Neuroimmunol 125(1-2):59-65 |
| abstractText | Fractalkine (FKN), also known as neurotactin, is a CX(3)C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX(3)CR1 on leukocytes and microglia. We generated FKN-deficient mice to study the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-deficient mice had a 28% reduction in infarction size and lower mortality rate, when compared to wild-type littermates. The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia. |
