| First Author | Sawa S | Year | 2011 |
| Journal | Nat Immunol | Volume | 12 |
| Issue | 4 | Pages | 320-6 |
| PubMed ID | 21336274 | Mgi Jnum | J:170464 |
| Mgi Id | MGI:4946544 | Doi | 10.1038/ni.2002 |
| Citation | Sawa S, et al. (2011) RORgammat(+) innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol 12(4):320-6 |
| abstractText | Lymphoid cells that express the nuclear hormone receptor RORgammat are involved in containment of the large intestinal microbiota and defense against pathogens through the production of interleukin 17 (IL-17) and IL-22. They include adaptive IL-17-producing helper T cells (T(H)17 cells), as well as innate lymphoid cells (ILCs) such as lymphoid tissue-inducer (LTi) cells and IL-22-producing NKp46(+) cells. Here we show that in contrast to T(H)17 cells, both types of RORgammat(+) ILCs constitutively produced most of the intestinal IL-22 and that the symbiotic microbiota repressed this function through epithelial expression of IL-25. This function was greater in the absence of adaptive immunity and was fully restored and required after epithelial damage, which demonstrates a central role for RORgammat(+) ILCs in intestinal homeostasis. Our data identify a finely tuned equilibrium among intestinal symbionts, adaptive immunity and RORgammat(+) ILCs. |
