| First Author | Stumhofer JS | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 5 | Pages | e62889 |
| PubMed ID | 23667536 | Mgi Jnum | J:202181 |
| Mgi Id | MGI:5517629 | Doi | 10.1371/journal.pone.0062889 |
| Citation | Stumhofer JS, et al. (2013) IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection. PLoS One 8(5):e62889 |
| abstractText | Previous studies have indicated that Il21r (-/-) mice chronically infected with Toxoplasma gondii display a defect in serum IgG; however, the basis for this antibody defect was not defined and questions remain about the role of IL-21 in promoting the production of IL-10, which is required to limit infection-induced pathology during toxoplasmosis. Therefore, Il21 (-/-) mice were challenged with T. gondii to determine whether IL-21 impacts the parasite-specific CD8(+) T cell response, its contribution to thymus-dependent antibody production after infection, and balance between protective and pathogenic responses. Whereas IL-21 has been implicated in the differentiation of IL-10 producing CD4(+) T cells no immune-mediated pathology was evident in Il21 (-/-) mice during the acute response, nor was there a defect in the development of this population in chronically infected Il21 (-/-) mice. However, Il21 (-/-) mice displayed a defect in IgG production after infection that correlated with a decrease in GC B cell numbers, the CD4(+) and CD8(+) T cell numbers in the brain were reduced over the course of the chronic infection leading to a decrease in total IFN-gamma production and an increase in parasite numbers associated with susceptibility to toxoplasmic encephalitis. Together, these results identify a key role for IL-21 in shaping the humoral and cellular response to T. gondii, but indicate that IL-21 has a limited role in regulating immunopathology. |
