| First Author | Hashimoto A | Year | 2008 |
| Journal | Eur J Pharmacol | Volume | 586 |
| Issue | 1-3 | Pages | 221-5 |
| PubMed ID | 18448092 | Mgi Jnum | J:141701 |
| Mgi Id | MGI:3819293 | Doi | 10.1016/j.ejphar.2008.03.031 |
| Citation | Hashimoto A, et al. (2008) Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy. Eur J Pharmacol 586(1-3):221-5 |
| abstractText | The behavioral effects induced by methamphetamine (5.0 mg/kg) were compared in the mutant mice lacking d-amino acid oxidase activity and normal mice. The mutant mice exhibited marked decline in the methamphetamine-induced stereotypy compared to the normal mice, whereas the mutant mice displayed a drastic augmentation in the locomotor activity evoked by methamphetamine compared to the normal mice. Because the d-serine levels in the brain of the mutant mice are significantly higher than those in the normal mice, the enhanced d-serine in the brain of the mutant mice could antagonize the methamphetamine-induced stereotypy via the N-methyl-d-aspartate receptors. |
