| First Author | Verta R | Year | 2021 |
| Journal | Biomolecules | Volume | 11 |
| Issue | 10 | PubMed ID | 34680152 |
| Mgi Jnum | J:323066 | Mgi Id | MGI:6784306 |
| Doi | 10.3390/biom11101517 | Citation | Verta R, et al. (2021) The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice. Biomolecules 11(10) |
| abstractText | Previous studies implicated the histamine H4 receptor in renal pathophysiology. The aim here is to elucidate the role of this receptor on renal function using H4 receptor knockout mice (H4R(-/-)). Healthy and diabetic H4R(-/-) mice compared to their C57BL/6J wild-type counterpart for renal function and the expression of crucial tubular proteins. H4R(-/-) and wild-type mice, matched for ages, showed comparable weight gain curves reaching similar median weight at the end of the study. However, H4R(-/-) mice displayed a higher basal glycemia. H4R(-/-) mice showed a lower urine 24 h outflow, and albumin-to-creatinine ratio (ACR) compared to wild-type mice. Consistently, H4R(-/-) mice presented a higher expression of megalin and a lower basal expression of the sodium-hydrogen exchanger (NHE)3 and aquaporin (AQP)2. According to these basal differences, diabetic H4R(-/-) mice developed more severe hyperglycemia and a higher 24 h urine volume, but a lower increase in ACR and decrease in urine pH were observed. These events were paralleled by a reduced NHE3 over-expression and megalin loss in diabetic H4R(-/-) mice. The AQP1 and AQP7 patterns were also different between H4R(-/-) and wild-type diabetic mice. The collected results highlight the role of the histamine H4 receptor in the control of renal reabsorption processes, particularly albumin uptake. |
