| First Author | Wiggins SV | Year | 2023 |
| Journal | J Ocul Pharmacol Ther | Volume | 39 |
| Issue | 5 | Pages | 317-323 |
| PubMed ID | 37097314 | Mgi Jnum | J:350566 |
| Mgi Id | MGI:7663206 | Doi | 10.1089/jop.2022.0180 |
| Citation | Wiggins SV, et al. (2023) Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase. J Ocul Pharmacol Ther 39(5):317-323 |
| abstractText | Purpose: We investigated whether a clinically used carbonic anhydrase inhibitor (CAIs) can modulate intraocular pressure (IOP) through soluble adenylyl cyclase (sAC) signaling. Methods: IOP was measured 1 h after topical treatment with brinzolamide, a topically applied and clinically used CAIs, using direct cannulation of the anterior chamber in sAC knockout (KO) mice or C57BL/6J mice in the presence or absence of the sAC inhibitor (TDI-10229). Results: Mice treated with the sAC inhibitor TDI-10229 had elevated IOP. CAIs treatment significantly decreased increased intraocular pressure (IOP) in wild-type, sAC KO mice, as well as TDI-10229-treated mice. Conclusions: Inhibiting carbonic anhydrase reduces IOP independently from sAC in mice. Our studies suggest that the signaling cascade by which brinzolamide regulates IOP does not involve sAC. |
