| First Author | Sabino V | Year | 2009 |
| Journal | Behav Brain Res | Volume | 198 |
| Issue | 2 | Pages | 472-6 |
| PubMed ID | 19100292 | Mgi Jnum | J:145735 |
| Mgi Id | MGI:3835904 | Doi | 10.1016/j.bbr.2008.11.036 |
| Citation | Sabino V, et al. (2009) Sigma-1 receptor knockout mice display a depressive-like phenotype. Behav Brain Res 198(2):472-6 |
| abstractText | Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior. |
