| First Author | Xu F | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 21 | Pages | 3924-31 |
| PubMed ID | 25240194 | Mgi Jnum | J:216352 |
| Mgi Id | MGI:5608706 | Doi | 10.1016/j.febslet.2014.09.004 |
| Citation | Xu F, et al. (2014) Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse. FEBS Lett 588(21):3924-31 |
| abstractText | Quinonoid dihydropteridine reductase (QDPR) catalyzes the regeneration of tetrahydrobiopterin (BH4), a cofactor for monoamine synthesis, phenylalanine hydroxylation and nitric oxide production. Here, we produced and analyzed a transgenic Qdpr(-/-) mouse model. Unexpectedly, the BH4 contents in the Qdpr(-/-) mice were not decreased and even increased in some tissues, whereas those of the oxidized form dihydrobiopterin (BH2) were significantly increased. We demonstrated that unlike the wild-type mice, dihydrofolate reductase regenerated BH4 from BH2 in the mutants. Furthermore, we revealed wide alterations in folate-associated metabolism in the Qdpr(-/-) mice, which suggests an interconnection between folate and biopterin metabolism in the transgenic mouse model. |
