| First Author | Buzzi B | Year | 2023 |
| Journal | Brain Res | Volume | 1817 |
| Pages | 148483 | PubMed ID | 37442250 |
| Mgi Jnum | J:338571 | Mgi Id | MGI:7513622 |
| Doi | 10.1016/j.brainres.2023.148483 | Citation | Buzzi B, et al. (2023) Differential roles of diacylglycerol lipase (DAGL) enzymes in nicotine withdrawal. Brain Res 1817:148483 |
| abstractText | Nicotine and tobacco-related deaths remains a leading cause of preventable death and disease in the United States. Several studies indicate that modulation of the endocannabinoid system, primarily of the endocannabinoid 2-Arachidonoylglycerol (2-AG), alters nicotinic dependence behaviors in rodents. This study, using transgenic knock-out (KO) mice, evaluated the role of the two 2-AG biosynthesis enzymes, (Diacylglycerol lipase-alpha) DAGL-alpha and DAGL-beta in spontaneous nicotine withdrawal. DAGL-alpha deletion prevents somatic and affective signs of nicotine withdrawal, while DAGL-beta deletion plays a role in hyperalgesia due to nicotine withdrawal. These results suggest a differential role of these enzymes in the various signs of nicotine withdrawal. Our behavioral findings relate to the distribution of these enzymes with DAGL-beta being highly expressed in macrophages and DAGL-alpha in neurons. This study offers new potential targets for smoking cessation therapies. |
